SAMHITA | Volume 1 | Issue 2 | 2023
Editorial
WELCOME MESSAGE FROM THE EDITOR-IN-CHIEF BMUSMDRJ.2023.1.2.0
Abstract
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Review Article
A Review on Novel Approaches to the Treatment of Asthma BMUSMDRJ.2023.1.2.1
Abstract
Asthma is among the most prevalent disorders of the respiratory system, affecting more than 300 million people worldwide. It is a heterogeneous and intricate inflammatory disease of the airways with complicated underlying events yet to be unleashed. Despite of advances in the introduction of newer therapies, the symptoms and exacerbations caused by asthma continue to prevail. Hence, there is an emerging need for new drug delivery mechanisms to achieve therapy unrestricted to symptomatic relief as well as to overcome the hindrances faced by conventional drug delivery systems. The present review highlights a brief overview of the disease and the rising superiority of novel drug delivery systems over conventional systems in its treatment and prevention.
Quest for Identity in That Long Silence by Shashi Deshpande BMUSMDRJ.2023.1.2.2
Abstract
Feminism plays pivotal role to lift up the life of Indian women in man dominated society. The true spirit of feminism is to look at man and woman as equal human being. The present research focuses on dilemma of woman in man dominated world, the plight of women and problems faced by women in India, especially their position in family and society. The present paper attempts to study Shashi Deshpande's women characters, her portrayal of women needs to be studied from a feminist angle. As an author of the '70s and 80s', she mirrors a realistic picture of the contemporary middle-class, educated, urban Indian woman through the character of Jaya. Through her novel That Long Silence, she portrays the miserable plight of the contemporary middleclass, urban Indian woman and also analyze how their life has not changed much even in the twentieth century. This paper discusses the dilemma of a married woman living in anguish and helplessness. In her loneliness, Jaya goes through a self- evaluation of her life and identity. This paper tries to illuminate the impact of silence in Indian women’s life and Jaya’s overcoming of it. The study tries to understand what makes a woman to stay silent and what eventually forces her to speak up.
Nanosuspension: Novel Approach for Drug Delivery BMUSMDRJ.2023.1.2.3
Abstract
Nanosuspensions have emerged as a encouraging strategy for the efficient delivery of hydrophobic drugs because of their multipurpose features and unique advantages. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emulsions and microemulsions as templates has been addressed in the literature. The unique features of nanosuspensions have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels. Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery.
Leveraging Machine Learning to Strengthen Cybersecurity: Addressing Challenges and Embracing Opportunities BMUSMDRJ.2023.1.2.4
Abstract
As the internet evolves, cyber threats are constantly changing, posing challenges to the cybersecurity landscape. This paper focuses on the significance of data in machine learning and deep learning within the context of cybersecurity. It explores common network datasets used in machine learning and deep learning and discusses the difficulties associated with applying these techniques in cybersecurity. The evolution of malware, particularly the rise of bot malware and the formation of botnets, underscores the importance of analyzing network traffic to identify compromised machines. The paper aims to provide security professionals with insights into the application of machine learning techniques for detecting intrusion, malware, and spam. The goal is to improve detection and response capabilities in the dynamic field of cybersecurity. While machine learning shows promise, its effective use in cybersecurity requires ongoing exploration and refinement. By staying informed about emerging threats and continuously improving machine learning algorithms, we can strengthen our defenses against cyber-attacks and protect critical systems and data.
Research Article
HPLC Method Development and Validation of Artesunate and Amodiaquine in Tablet Dosage Form BMUSMDRJ.2023.1.2.5
Abstract
An accurate and precise HPLC method was developed and validated for simultaneous estimation of Amodiaquine and Artesunate in tablet dosage form. The column was used was C18 column (150 x 4.6mm, 5μm) column and a mobile phase composed of Potassium Dihydrogen o-Phosphate Buffer (pH-5): Acetonitrile (50:50 v/v). The flow rate was kept 1 ml/min and the detection wavelength was 280nm. The retention time for Amodiaquine and Artesunate was found to be 3.1 min and 5.3 min respectively. The linearity range was found to be 12.5-37.5 μg/ml for Artesunate with corelation coefficient 0.999 and 32.5-97.5 μg/ml for Amodiaquine corelation coefficient 0.9999 for Artesunate and Amodiaquine respectively. The LOD and LOQ for Artesunate 0.32 and 0.97 μg/ml was found to be and for Amodiaquine was found to be 0.50 and 0.82 respectively. The repeatability, intraday and interday precision was found to be less than 2%. The proposed methods for estimation of Amodiaquine and Artesunate were found to be selective, precise and accurate. The developed validated method is applicable for the simultaneous determination of Amodiaquine and Artesunate in tablet dosage form.
A Study on Regulatory Requirement for Development of Cardiac Pacemaker In USA BMUSMDRJ.2023.1.2.6
Abstract
Cardiac pacing is an emerging lifesaving procedure that is being widely used in the recent times. Therefore, it is considered vital for the healthcare professionals to be aware of patients knowledge and experience after the cardiac device implantation and also the impact these implanted devices have on their day-to-day life. This study was conducted with an aim to assess the knowledge and attitude of patients regarding permanent pacemakers (PMs) and their quality of life (QOL) after the permanent PM implantation. A descriptive cross-sectional study design was used in this study. A total of seventy patients were chosen by total enumerative sampling technique among those patients attending the cardiology outpatient department, PM clinic and selected cardiology wards of a tertiary care centre in South India. A significant association between attitude and age was found. Conscious effort must be taken to help patients cope better and experience good QOL through systematic teaching after the PM implantation. This will help patients to function maximally and live life to their best capacities in the family and society.
Unfolding: Mixed-Used Vertical Neighborhood in Mumbai BMUSMDRJ.2023.1.2.7
Abstract
Indian metropolitan cities are shifting towards taller buildings and compact living spaces due to rapid urbanization and influx of population. Previously, cities developed horizontally but are now developing vertically. This is due to the high rate of population migration to metro cities, leading to higher population density. According to a survey by World Bank, India is expected to experience a surge in urban population by 2050. In order to improve living conditions in densely populated areas and meet future needs, steps must be taken to bring together essential human necessities in a sustainable manner, including incorporating more green spaces and urban farming into development projects. The goal is to create a mixed-use development that meets the essential needs of people in the future. This development will include three types of spaces: a private space for personal needs, a space for economic engagement, and a more flexible space for building social bonds and community identity. The development will be organized vertically, with multiple layers that provide easy access to all necessary resources. The concept of a vertical city involves creating a high-end housing infrastructure that also provides a complex network of functions typically found in a horizontal city. The goal is to balance comfort and elegance in the user lifestyle. This concept is a prototype solution for future Indian cities and can be replicated to more efficiently face upcoming urban challenges.